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Alexander-Miller, Martha
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Academic Article Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression.
Academic Article A novel CD8-independent high-avidity cytotoxic T-lymphocyte response directed against an epitope in the phosphoprotein of the paramyxovirus simian virus 5.
Academic Article Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice.
Academic Article Molecular mechanisms and biological significance of CTL avidity.
Academic Article High avidity CD8+ T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation.
Academic Article Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection.
Academic Article Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules.
Academic Article A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function.
Academic Article Transferable anticancer innate immunity in spontaneous regression/complete resistance mice.
Academic Article Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naïve CD8+ T cells: a potential mechanism for direct presentation.
Academic Article Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5.
Academic Article TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways.
Academic Article Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells.
Academic Article Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen.
Academic Article Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus.
Academic Article Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1.
Academic Article IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment.
Academic Article Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung.
Academic Article Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.
Academic Article Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions.
Academic Article Specific prolongation of allograft survival by a T-cell-receptor-derived peptide.
Academic Article Biased T cell receptor usage by Ld-restricted, tum- peptide-specific cytotoxic T lymphocyte clones.
Academic Article Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases.
Academic Article Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes.
Academic Article An abrupt and concordant initiation of apoptosis: antigen-dependent death of CD8+ CTL.
Academic Article High avidity cytotoxic T lymphocytes to a foreign antigen are efficiently activated following immunization with a recombinant paramyxovirus, simian virus 5.
Academic Article Suppressed cytotoxic T lymphocyte responses in experimental cysticercosis.
Academic Article Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity.
Academic Article High avidity CD8+ T cells are the initial population elicited following viral infection of the respiratory tract.
Academic Article High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors.
Academic Article Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract.
Academic Article Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes.
Academic Article Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors.
Academic Article Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter.
Academic Article Loss of function in virus-specific lung effector T cells is independent of infection.
Academic Article Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus.
Academic Article Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function.
Academic Article Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection.
Academic Article Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction.
Academic Article Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization.
Academic Article CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation.
Academic Article Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity.
Academic Article Expression of HLA class I molecules and the transporter associated with antigen processing in hepatocellular carcinoma.
Academic Article Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.
Academic Article Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-envelope protein to human cytotoxic T lymphocytes.
Academic Article Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.
Academic Article Cytotoxic T lymphocyte (CTL) adherence assay (CAA): a non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes.
Academic Article Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection.
Concept MAP Kinase Signaling System
Concept Humans
Concept Antigens, Differentiation, T-Lymphocyte
Concept Down-Regulation
Concept Jurkat Cells
Concept Biofilms
Concept Cell Movement
Concept Antigen Presentation
Concept Primates
Concept Hematopoietic Stem Cells
Concept Sirtuin 1
Concept Protein Structure, Tertiary
Concept Lymphocytes
Concept Proto-Oncogene Proteins c-myc
Concept Monosaccharide Transport Proteins
Concept Vaccinia virus
Concept Caspases
Concept Cricetinae
Concept Aorta
Concept Interleukin-17
Concept Antigens, Surface
Concept Cytoplasmic Granules
Concept ATP-Binding Cassette Transporters
Concept Weight Loss
Concept Atherosclerosis
Concept Lymphocyte Activation
Concept Antigens, Viral
Concept Leukocytes, Mononuclear
Concept Carcinoma, Hepatocellular
Concept Th1 Cells
Concept Antibody Affinity
Concept Hemolysis
Concept Blotting, Northern
Concept Antigens, Neoplasm
Concept Myeloid Differentiation Factor 88
Concept Aged
Concept Proto-Oncogene Proteins c-bcl-2
Concept Electrophysiology
Concept STAT5 Transcription Factor
Concept Amino Acid Sequence
Concept Receptors, G-Protein-Coupled
Concept Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Concept Mice, Knockout
Concept HIV Envelope Protein gp160
Concept Mice, Inbred C3H
Concept Calcium
Concept Antibodies, Viral
Concept Blotting, Western
Concept Histocompatibility Antigens Class I
Concept T-Lymphocytes, Regulatory
Concept Cricetulus
Concept T-Lymphocyte Subsets
Concept Membrane Microdomains
Concept Up-Regulation
Concept Caspase 3
Concept Cysticercosis
Concept Autocrine Communication
Concept Mice
Concept Administration, Intranasal
Concept Aging
Concept Bone Marrow Cells
Concept Complement Inactivator Proteins
Concept Kinetics
Concept Receptors, Tumor Necrosis Factor, Type II
Concept Integrin alpha Chains
Concept HIV Envelope Protein gp120
Concept Leukocytes
Concept Tumor Necrosis Factor-alpha
Concept Frail Elderly
Concept Mice, Inbred C57BL
Concept Enzyme Activation
Concept HLA-A2 Antigen
Concept Neoplasm Regression, Spontaneous
Concept Blood Platelets
Concept Mice, Transgenic
Concept T-Lymphocytes
Concept Antigens, Bacterial
Concept Antigens, CD
Concept Signal Transduction
Concept Monocytes
Concept Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Concept Immunoglobulin G
Concept Platelet Adhesiveness
Concept Antigens, Ly
Concept HIV Antigens
Concept Blotting, Southern
Concept Enzyme-Linked Immunosorbent Assay
Concept Protein Binding
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Neutrophils
Concept T-Lymphocytes, Cytotoxic
Concept Apoptosis
Concept Interleukin-10
Concept Protein Transport
Concept Hemagglutinins
Concept Antigens
Concept Caspase 1
Concept Interleukin-2 Receptor alpha Subunit
Concept Receptors, Antigen, T-Cell
Concept Flow Cytometry
Concept Apolipoproteins E
Concept Hela Cells
Concept Symbiosis
Concept TNF Receptor-Associated Factor 2
Concept Mice, Inbred BALB C
Concept Imidazoles
Concept Bacterial Adhesion
Concept CD8-Positive T-Lymphocytes
Concept B-Lymphocyte Subsets
Concept Calcium Channels
Concept Antibodies, Neutralizing
Concept Mice, Nude
Concept Lymphocytic choriomeningitis virus
Concept Mice, SCID
Concept Mice, Inbred Strains
Concept Calcium Signaling
Concept Nitrites
Concept Histocompatibility Antigens Class II
Concept CD4-Positive T-Lymphocytes
Concept Antigen-Presenting Cells
Concept Interleukin-12
Concept H-2 Antigens
Concept Th2 Cells
Concept Histocompatibility Antigens
Concept STAT1 Transcription Factor
Concept B-Lymphocytes
Concept Host-Pathogen Interactions
Concept Protein Conformation
Concept Cholesterol
Concept Mice, Inbred DBA
Concept Anemia, Sickle Cell
Concept Annexin A5
Concept Structure-Activity Relationship
Concept Echium
Concept Base Sequence
Concept Killer Cells, Natural
Concept Immunohistochemistry
Concept Cytomegalovirus
Concept Cell Line, Tumor
Concept Lymphocyte Subsets
Concept RNA-Binding Proteins
Concept Lymphocyte Transfusion
Academic Article High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion.
Academic Article In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection.
Academic Article Paramyxovirus activation and inhibition of innate immune responses.
Academic Article CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals.
Academic Article Influenza A virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation.
Academic Article Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8? T cell response.
Academic Article Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges.
Academic Article Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection.
Academic Article Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes.
Academic Article Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.
Academic Article Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates.
Academic Article A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model.
Academic Article Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model.
Academic Article Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes.
Grant Control of T cell response during respiratory infection
Grant Control of cytotoxic T cell differentiation and activity
Grant Training Program in Immunology and Pathogenesis
Grant Regulation of avidity in T lymphocytes
Grant Vaccination strategies to overcome immune deficiencies in neonates
Grant CTL AVIDITY AND THE AGING IMMUNE RESPONSE
Grant Cellular Immune Response to Respiratory Infection
Academic Article Potential therapeutic action of nitrite in sickle cell disease.
Grant Immune regulation by pneumococcus
Academic Article An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non-human primate neonates.
Academic Article Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6months in a nonhuman primate neonate model.
Academic Article A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling.
Academic Article The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells.
Grant Effectiveness of R848 conjugated IPR8 as a vaccine for the elderly
Academic Article Immunogenicity of high-dose influenza vaccination in patients with primary central nervous system malignancy.
Grant Development of vaccine approaches to elicit broadly protective influenza-specific immune responses in infants
Academic Article SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis.
Academic Article Understanding Antibody Responses in Early Life: Baby Steps towards Developing an Effective Influenza Vaccine.
Academic Article Challenges for the Newborn Following Influenza Virus Infection and Prospects for an Effective Vaccine.
Academic Article Higher Frequency and Increased Expression of Molecules Associated with Suppression on T Regulatory Cells from Newborn Compared with Adult Nonhuman Primates.
Academic Article TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8+ T Cell Activation Setpoint.
Academic Article Influenza-infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin stem.
Academic Article Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti-PD-1 Immune Checkpoint Blockade.
Academic Article An Analysis of Linker-Dependent Effects on the APC Activation and In Vivo Immunogenicity of an R848-Conjugated Influenza Vaccine.
Academic Article Maternal influenza vaccination preferentially boosts hemagglutinin stem-specific antibody resulting in efficient transplacental transfer of stem-specific IgG.
Academic Article Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults.
Academic Article Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response.
Academic Article TLR agonists induce sustained IgG to hemagglutinin stem and modulate T cells following newborn vaccination.
Academic Article Frailty and Age Impact Immune Responses to Moderna COVID-19 mRNA Vaccine.
Academic Article Analysis of R848 as an Adjuvant to Improve Inactivated Influenza Vaccine Immunogenicity in Elderly Nonhuman Primates.
Academic Article Frailty and COVID-19 mRNA Vaccine Antibody Response in the COVID-19 Community Research Partnership.
Academic Article Neuraminidase-specific antibody responses are generated in naive and vaccinated newborn nonhuman primates following virus infection.
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